When I scan negatives, I try to capture as much information as possible that goes into the editing process. Don’t forget that you can throw it away later, once your final result is there. Or you can keep it (for certain photos) to edit them later.
I described the essence of my process here:
So I would definitely recommend a high bit depth. I’m also considering to increase the resolution. Currently I use 3200 dpi (for medium format, 6x7) and it might be interesting to play with higher resolutions in order to do some oversampling and to finally achieve a better quality in a down-scaled export.