GIMP-2.10 doesn’t support Lanczos, it has NoHalo and LoHalo. NoHalo is a little sharper than LoHalo.
The nature of a given resizing algorithm will decide whether you need any post-resize sharpening, and how much. I like Lanczos because its downscaled output looks sharp while not suffering from aliasing. GIMP’s Lo/NoHalo are fine too, though a bit softer.
For sharpening I typically use USM with a contrast threshold in RawTherapee. I only use RL Deconvolution when needed, as it can sometimes exaggerate bright points making them look like noise.
Do your own tests. Areas to pay attention to are those with a fine repetitive pattern, diagonals, thin lines, high contrast edges.
See here:
It’s just the implementation you’re using which is slow - find a different implementation, e.g. RL in RT is fast. GIMP-2.10 is currently slow in general - the plan I read is to perform optimization last, once the dev team are done implementing new features.