Just run into an issue, which might be a bug (or a flatpak issue or something else).
Using G’mic under Gimp (3.0.4, flatpak version) I was trying to apply RL sharpening to a JPG image with an AdobeRGB color profile (upon opening the image I opted for keeping this profile), but then I ended up with a completely black image.
Doing the same operation after having the image converted to sRGB upon import works fine. Likewise, using G’mic RL sharpen on the command line on the image with the AdobeRGB profile works ok. So it seems to be an issue with G’mic (3.6.1) in combination with Gimp or the flatpak implementation thereof.