Super annoying gtk menu focus bug impacting MacOS Ventura has been fixed here macos13: presets menu doesn't get focus for mouse actions · Issue #12727 · darktable-org/darktable · GitHub and here Preset's not selectable on MacOS Ventura · Issue #12708 · darktable-org/darktable · GitHub , I also suffer after upgrading to Ventura, the root issue has been fixed widgets not reacting to mouse hover/click on macOS Ventura (#5305) · Issues · GNOME / gtk · GitLab in Commits · gtk-3-24 · GNOME / gtk · GitLab . Hopefully it will buble up to 4.2.4 soon.
Work around (works 90% of time for me) Preset's not selectable on MacOS Ventura · Issue #12708 · darktable-org/darktable · GitHub