New bugginess with selecting drop-down presets list items

you might try the development build current OSX Build - #588 by MStraeten built with a patched gtk (just a workaround, there’s no solution merged yet)
But keep in mind, there’s no way back to 4.0.1, so do a backup of your ~/.config/darktable and the xmps in your image directories first.
Current master yet doesn’t include features not also included in upcoming official 4.2 release.