Can not open a RW2 file from Panasonic Lumix S5 II...any ideas why?

Well, it isn’t on the camera supported list, is it now?

Panasonic changed their compression algorithm and some recent cameras are not supported yet.*

* At least, not OOTB unless you make darktable use LibRaw as its raw loading backend for a particular raw file extension. Caveat emptor: this is an unsupported workaround.

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