I installed your 4.2.1396 not long after your post and things were ok at first. The only thing I noticed was with the default skin where the left column in the editor was taking up too much real estate and if you resize it over it bounces back out… TooWaBoo has had that one before with his skin. No big deal.
Last night I went back in to edit a shot and started getting ‘no disk’ errors. It started off with just one pass through all my drives before loading the image then got worse to where it seems like I’d have to go through eacg no disk screen multiple times before moving on. They also came up when loading profiles or saving/exporting. I uninstalled 4.2.1396 and reinstalled it but got the no disk messages right away that time… Uninstalled 4.2.1396 and went back to sguyader’s 4.2.1291 and the issue went away.